The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Evolution of streptococcal pathovars

Davies Group

Streptococcus dysgalactiae subspecies equisimilis (group C and G Streptococcus) is a human pathogen, mirroring the disease profile and colonising the same ecological niche as the well-documented human pathogen, Streptococcus pyogenes. The overlap in both pathogen lifestyle and disease repertoire along with evidence of gene transfer between these pathogens suggests that they may share common genetic mechanisms for causing disease. The primary aim of this project is to apply various bioinformatics approaches within global genome databases to identify candidate genes that drive streptococcal invasive disease and other pathogenic processes. This will also inform vaccine approaches to combat streptococcal disease.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Mark Davies

Project Co-supervisor

Associate Professor Steven Tong

Project availability
PhD/MPhil
Honours

Davies Group

mark.davies1@unimelb.edu.au

3 vacancies

Themes
Antimicrobial Resistance and Healthcare Associated Infections
Host Pathogens Interactions
Cross Cutting Disciplines
Discovery Research
Genomics
Indigenous Health
Public Health

The Davies group aims to apply genome sequencing methodologies and bioinformatics approaches to understand the evolution and transmission of bacterial pathogens. This knowledge can help facilitate a global understanding of pathogen evolution, in addition to informing public health intervention to reduce the disease burden associated with bacterial pathogens. Current projects address key research questions such as: is there a genetic difference between strains causing different disease manifestations? What is driving the emergence and dissemination of bacterial pathogens? Do host immune factors govern disease severity? Our research closely aligns with key international collaborators including the Wellcome Trust Sanger Institute in the United Kingdom.