The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Infection induced changes to splenic macrophages

Heath Group

There are multiple populations of macrophages in the spleen, which all have unique locations and functions. We previously showed that as a result of infection with blood stage malaria parasites, we see a CD8 T cell-mediated loss of two of the populations of macrophages, associated with a breakdown in the splenic architecture. We are now investigating this further to understand how CD8 T cells mediate this effect and determine if it has functional consequences for the development of immunity. This project will use advanced cellular immunology techniques including live imaging, immunohistology and flow cytometry.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Lynette Beattie

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Heath Group

lynette.beattie@unimelb.edu.au

3 vacancies

Themes
Host Pathogens Interactions
Immunology
Cross Cutting Disciplines
Discovery Research

The Heath group is interested in the immune response to pathogens, particularly to malaria, which is still a major cause of mortality worldwide. We study T cell responses with the aim of improving vaccine strategies and focus on T cell responses in the skin, the liver and lymphoid organs including the spleen. Our lab recently discovered a population of resident memory T cells within the liver that are capable of protecting against malaria infection. These and other cells are currently being studied. 


Heath Group Current Projects