The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

Project: Synergistic and antagonistic interplay between Streptococcus pneumoniae and respiratory viruses

Satzke Group

The contribution of bacterial-viral co-infections to the onset and severity of disease is increasingly attracting interest from researchers globally. Specifically, it is well established that co-infections of Streptococcus pneumoniae with respiratory viruses (e.g. influenza or respiratory syncytial virus) impact the severity of acute respiratory infections. This is because viral replication creates a more hospitable environment for pathogenic bacteria of the respiratory tract to flourish, predisposing individuals to a bacterial super infection. However, recent research has found that the interplay between pneumococci and viruses is more complex than previously anticipated. We, and others, have shown that some aspects of co-infection are synergistic (resulting in greater disease severity), while others are antagonistic, where the presence of one pathogen negatively impacts the other. In this project, you will elucidate the underlying microbiological and/or immunological mechanisms that govern the synergistic and antagonistic aspects of the interplay between pneumococci and respiratory viruses. Key approaches to this project include working with in vivo models as well as microbiological and immunological analysis of tissues from the respiratory tract. Your work will help us understand the complexities of pneumococcal-viral co-infection, including their implications for the effectiveness of vaccines targeting these pathogens.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Associate Professor Catherine Satzke

Project Co-supervisor

Dr Sam Manna

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Satzke Group

catherine.satzke@mcri.edu.au

2 vacancies

Themes
Host Pathogens Interactions
Cross Cutting Disciplines
Translational and Clinical Research
Epidemiology
Global Health

The Satzke group conducts research in a clinically-relevant context. We focus on the microbiology of two pathogens of major global health importance (pneumococcus and group A streptococcus) to understand their pathogenesis, interaction with viruses, and how infections can be best prevented with vaccines. We collaborate closely with immunologists, clinicians and epidemiologists, including in countries in the Asia-Pacific region, to facilitate translation and global impact.


Satzke Group Current Projects