The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: The importance of IgA in the protection and control of infectious diseases

Chung group

The human body produces more IgA than any other immunoglobulin, especially in mucosal secretions. However, the importance of IgA in both protection from HIV-1 and control of HIV-1 disease progression is highly controversial. Results from the only protective human HIV vaccine trial associated plasma IgA with reduced vaccine efficacy. In contrast, recent studies suggest that mucosal HIV-specific IgA may be protective. This project aims to further explore the mechanisms behind both the protective and immunomodulatory role of IgA in the control of HIV-1 and other infectious diseases.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Amy Chung

Project Co-supervisor

Professor Stephen Kent

Project availability
PhD/MPhil
Master of Biomedical Science

Chung group

awchung@unimelb.edu.au

3 vacancies

Themes
Immunology
Viral Infectious Diseases
Cross Cutting Disciplines
Discovery Research

The Chung group has an interest in understanding how an antibody can instruct the innate immune system to attack and protect against a range of infectious diseases including HIV, Mycobacterium tuberculosis and malaria through engagement with their Fc regions. Ultimately, our research aims to understand the mechanisms behind these antibodies in order to guide the development of more effective antibody therapeutics and vaccines.


Chung group Current Projects