The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Whole body analysis of human tissue-resident memory T cells

Mackay, Laura Group

The majority of T cell responses occur in tissues, however, our knowledge of human T cells is largely derived from blood. In collaboration with surgeons from Austin Health and DonateLife, we have access to samples from multiple lymphoid, visceral and barrier sites from research-consented organ donors. Using our unique resource, this project will investigate the pathways that guide tissue-resident memory T cells (TRM) differentiation and maintenance in diverse tissue sites, with the overall goal of developing therapies and vaccines that manipulate TRM.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Claire Gordon

Project Co-supervisor

Associate Professor Laura Mackay

Project availability
PhD/MPhil

Mackay, Laura Group

lkmackay@unimelb.edu.au

1 vacancies

Themes
Immunology
Viral Infectious Diseases
Cross Cutting Disciplines
Discovery Research

Research in the Mackay group has shown that specialised immune cells, called resident memory T cells, are critically important for protection against infection. These immune cells live in body tissues, where they stand guard at sites of pathogen invasion to directly combat infection. Within the Mackay lab, we aim to greatly enhance our fundamental understanding of resident memory T cell biology, and how these cells protect against disease. By learning to control these immune cells we can harness their protective function, with the ultimate goal of translating our basic discovery research into novel treatments for infectious disease, cancer and autoimmune disease. 


Mackay, Laura Group Current Projects